Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT
The results of this study indicated that MSCs can alleviate IMQ-induced psoriasiform dermatitis in mice by upregulating serine metabolism. The key serine metabolism enzyme PSPH may enhance PINK1/Parkin-mediated mitochondrial autophagy in psoriatic HaCaT and inhibit NLRP3 inflammasome activation in HaCaT cells, thereby alleviating skin inflammatory responses and suppressing skin p roliferation in psoriatic mice.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0003-1686-8800)
- Ping Song (ORCID: https://orcid.org/0000-0002-5558-9890)
- Qing Lin (ORCID: https://orcid.org/0000-0003-4889-443X)
- Rongjia Zhu (ORCID: https://orcid.org/0009-0008-9769-936X)
- Robert chunhua Zhao
- Yunfei Ji
Institutions
- State Grid Corporation of China (China) (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Academy of Artificial Intelligence (CN)
- IBM Research (China) (CN)
- Xiyuan Hospital (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1186/s13287-026-04964-z
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00