Bibliometric Analysis on Twin-Twin Transfusion Syndrome between 2000-2025

Aim: Twin-to-Twin Transfusion Syndrome (TTTS) is a serious complication of the monochorionic twin pregnancies triggered by placental blood shunting. When left untreated, the fetal mortality rate is high and thus it is an issue of major significance in medical science. This study presents a bibliometric analysis of literature to evaluate research productivity and trends. Material and Method: Articles and reviews, written in English, on TTTS published between 1 January 2000 and 15 August 2025 were identified using Web of Science Core Collection. Collaboration networks and keyword clusters were extracted using VOSviewer for analysis. Results: A total of 1062 papers were found, 930 (87.5%) were research papers. The publication output grew significantly between 2000–2025, with its recent decrease.Most frequently cited papers were related to fetal heart disease, treatment, and outcome. Conclusion: TTTS investigation developed remarkably in the past decade, especially in the aspect of diagnosis, therapy and its complications.