Autonomic- Immunoinflammatory-Cardiac Interplay during Lipopolysaccharide-Induced Systemic Inflammation

LPS-induced endotoxemia in rats leads to pronounced autonomic and inflammatory dysregulation, accompanied by distinct ECG abnormalities and reduced VNIM. The integration of HRV, cytokine, and ECG profiling provides valuable insight into the autonomic-inflammatory-cardiac interplay during systemic inflammation, supporting their utility in early diagnosis and monitoring of sepsis and related conditions.