Exercise increases transglutaminase 2 expression in skeletal muscle

Transglutaminase 2 (TG2) promotes skeletal muscle hypertrophy as a myokine. The expression levels of Tg2 mRNA increased with endurance exercise and were positively correlated with the expression level of Pgc-1α4 mRNA. PGC-1α4 increased Tg2 mRNA expression in cooperation with ATF6α. These findings suggest that the expression level of Tg2 mRNA increases during endurance exercise via ATF-6α and PGC-1α4.

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Publication Details

Journal
Bioscience Biotechnology and Biochemistry
Published
2026-03-26
DOI
https://doi.org/10.1093/bbb/zbag047
Primary Topic
Blood properties and coagulation
Type
article
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article

Exercise increases transglutaminase 2 expression in skeletal muscle

Tomoya Kitakaze, Ryoichi Yamaji, Yuki Kishi, Naoki Harada et al.
Bioscience Biotechnology and Biochemistry
Blood properties and coagulation
article

Exercise increases transglutaminase 2 expression in skeletal muscle

Tomoya Kitakaze, Ryoichi Yamaji, Yuki Kishi, Naoki Harada, Manami Dokan
article en

Abstract

Transglutaminase 2 (TG2) promotes skeletal muscle hypertrophy as a myokine. The expression levels of Tg2 mRNA increased with endurance exercise and were positively correlated with the expression level of Pgc-1α4 mRNA. PGC-1α4 increased Tg2 mRNA expression in cooperation with ATF6α. These findings suggest that the expression level of Tg2 mRNA increases during endurance exercise via ATF-6α and PGC-1α4.

Bioscience Biotechnology and Biochemistry
Osaka Prefecture University (JP)
Partnerships for the goals
Openalex Percentile: Top 3%
Blood properties and coagulation
DOISourceOpenAlex
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Exercise increases transglutaminase 2 expression in skeletal muscle — Tomoya Kitakaze, Ryoichi Yamaji, et al. · Bioscience Biotechnology and Biochemistry (2026) | TGRS Research Map | TGRS