Combination of quantitative MRI and laboratory markers for the detection and staging of metabolic dysfunction-associated steatotic liver disease
Question Refinement of non-invasive tools is needed to accurately stage metabolic-associated steatotic liver disease (MASLD), particularly progressive disease and significant and advanced fibrosis. Findings Quantitative MRI has good diagnostic accuracy to stage MASLD. The combination of MRI parameters with laboratory and anthropometric measurements has limited additional benefit. Clinical relevance This research provides valuable insights for clinicians seeking to reduce reliance on liver biopsy. The findings could be applied in clinical settings to guide earlier, less invasive diagnosis and disease monitoring, allowing for timely interventions and more personalized treatment strategies.
Authors
- Elizabeth Shumbayawonda (ORCID: https://orcid.org/0000-0003-0351-2063)
- Anne‐Marieke van Dijk (ORCID: https://orcid.org/0000-0003-0831-527X)
- Stan Driessen (ORCID: https://orcid.org/0000-0003-1485-9732)
- Koen C. van Son (ORCID: https://orcid.org/0000-0001-8329-3715)
- Julia J. Witjes (ORCID: https://orcid.org/0000-0002-3622-8731)
- Marian Troelstra (ORCID: https://orcid.org/0000-0001-6748-4810)
- Diona Zwirs
- Veera Houttu (ORCID: https://orcid.org/0000-0002-6430-7007)
- Bas Voermans (ORCID: https://orcid.org/0000-0002-6187-070X)
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Kirsi. M. A. van Eekhout
- Joanne Verheij (ORCID: https://orcid.org/0000-0003-1283-630X)
- A. J. Nederveen
- Oliver Gurney-Champion
- Max Nieuwdorp
- Anne Line Mak
- Nienke P. M. Wassenaar
- Adriaan G. Holleboom
Institutions
- Erasmus MC (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Radiology
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1007/s00330-026-12451-5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00