The behavioural effects of the serotonin 1A receptor agonist buspirone on reward processing in healthy volunteers: A randomised, placebo-controlled study
Speculatively, this could indicate that acute 5-HT<sub>1A</sub> agonism may worsen several stages of aversive processing, with minimal effect on reward processing. The study was pre-registered (clinicaltrials.gov, Serotonin-receptor Agonism in Reward Processing, NCT05357547).
Authors
- C. Harmer
- Sorcha Hamilton (ORCID: https://orcid.org/0000-0002-4702-5788)
- Alexander L. W. Smith (ORCID: https://orcid.org/0000-0003-1052-0096)
- Susannah E. Murphy (ORCID: https://orcid.org/0000-0001-8995-2099)
- Philip J. Cowen
Institutions
- Oxford Health NHS Foundation Trust (GB)
- Warneford Hospital (GB)
- University of Oxford (GB)
- University of Bath (GB)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1177/02698811261430527
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00