4-OI improves mitochondria-associated endoplasmic reticulum membrane dysfunction by regulating MFN2 through Nrf2 transcription and alleviates airway inflammation in asthma exposed to PM2.5 early in life
In summary, our research demonstrated found that 4-OI improved the dysfunction of mitochondria-associated endoplasmic reticulum membranes by modulating MFN2 <i>via</i> Nrf2 transcription, thereby reducing the inflammatory response in asthmatic airways during early exposure to PM2.5.
Authors
- Rui Zhou (ORCID: https://orcid.org/0000-0002-7903-9965)
- Siwei Wang (ORCID: https://orcid.org/0000-0002-4399-3212)
- Jiaxin Xu
- Lei Wang
- Juan Li
Institutions
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Inhalation Toxicology
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1080/08958378.2026.2650614
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00