Low‐Intensity Pulsed Ultrasound Promotes Spinal Cord Injury Recovery by Regulating Microglia‐Mediated Neuroinflammation
LIPUS effectively alleviates neuroinflammation after SCI and promotes neurological function recovery by regulating microglia-mediated neuroinflammation, whose mechanism is associated with the modulation of NOD-like receptor, IL-17 signaling pathways and the downregulation of hub genes such as CXCR2. This study provides a scientific basis for the clinical application of LIPUS in SCI treatment and a theoretical foundation for exploring multi-modal therapeutic strategies combining LIPUS with other therapies.
Authors
- Xiao Li (ORCID: https://orcid.org/0000-0002-3577-7915)
- Wanghui Liu
- Xiaoyi Zhou (ORCID: https://orcid.org/0000-0003-0264-6342)
- Hongji Zhong
- Zixiang Deng
- Tian Wang
- Hanfei Shang
- Yang Liu
- XianZhao Wei
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1002/cns.70849
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00