The Impact of Lactobacillus plantarum 299v as a Probiotic in Iron-deficiency Anemia Patients

Abstract: BACKGROUND: Iron-deficiency anemia (IDA) is one of the common nutritional disorders affecting 30% of the world’s population. This study aimed to identify the impact of probiotics in increasing iron absorption and treatment anemia disease using specific biological mechanisms. MATERIALS AND METHODS: The study is a clinical trial that randomly controlled on 100 Iraqi IDA patients. The group were divided into two groups: IDA intake 20 billion colony-forming units (CFU) of Lactobacillus plantarum 299v (LP299v) and 6 billion CFU of the same spp. in comparison to the control group who never intake any probiotics. RESULTS: The results showed that there is a significant increase in serum hemoglobin (HB), ferritin, iron, and reticulocyte HB content concentration in IDA patients treated with 20 billion CFU in comparison to control group (0.4 g/dl). CONCLUSION: The iron absorption in anemia patients was enhanced with a reduction in the side effect of iron supplementation after intake of LP299v Prebiotics. Therefore, it represents an effective adjuvant therapy choices of IDA.