Allogeneic Hematopoietic Cell Transplantation for Congenital Athymia: A Nationwide Retrospective Study in Japan

HCT can allow immune reconstitution in congenital athymia, although long-term survival is affected by comorbidities. Early diagnosis and timely intervention are crucial in managing this condition. HCT can be a restricted alternative therapy for patients ineligible for thymus implantation.

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Publication Details

Journal
Journal of Clinical Immunology
Published
2026-03-28
DOI
https://doi.org/10.1007/s10875-026-02008-y
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
0.00
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article

Allogeneic Hematopoietic Cell Transplantation for Congenital Athymia: A Nationwide Retrospective Study in Japan

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Journal of Clinical Immunology
Hematopoietic Stem Cell Transplantation
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Allogeneic Hematopoietic Cell Transplantation for Congenital Athymia: A Nationwide Retrospective Study in Japan

Motoshi Sonoda, Katsuhide Eguchi, Masataka Ishimura, Hideki Muramatsu, Koji Kawaguchi, Tsubasa Nishinosono, Takeshi Yamamoto, Manabu Wakamatsu, Takahiro Kudo, Michiko Kajiwara, Yoshiyuki Takahashi
article en

Abstract

HCT can allow immune reconstitution in congenital athymia, although long-term survival is affected by comorbidities. Early diagnosis and timely intervention are crucial in managing this condition. HCT can be a restricted alternative therapy for patients ineligible for thymus implantation.

Journal of Clinical Immunology
Kyushu University (JP), Chiba University (JP), Juntendo University (JP), Institute for Transfusion Medicine (US), Nagoya University Hospital (JP), Shizuoka Children's Hospital (JP), Nagoya University (JP)
Openalex Percentile: Top 3%
Hematopoietic Stem Cell Transplantation
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