Administration of an extrasynaptic δ-subunit GABA <sub>A</sub> receptor agonist in the prelimbic cortex attenuates methamphetamine sensitisation and relapse to methamphetamine-seeking behaviour in male rats
Selective activation of extrasynaptic PLC δ-subunit GABA<sub>A</sub> receptors reduced METH sensitisation and drug primed or cue-induced METH-seeking behaviour. These findings may aid development of effective pharmacotherapies for treating chronic METH use.
Authors
- Travis Wearne (ORCID: https://orcid.org/0000-0002-7565-9163)
- Gracie L Hay
- Nicholas A. Everett (ORCID: https://orcid.org/0000-0001-9226-6153)
- Jennifer L. Cornish (ORCID: https://orcid.org/0000-0002-9754-8069)
- Sarah J. Baracz (ORCID: https://orcid.org/0000-0002-9938-1936)
- Maarten van den Buuse
- Michael T. C. Hunter
- Jessica Roberts
Institutions
- The University of Sydney (AU)
- La Trobe University (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1177/02698811261430509
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00