A GABAergic neural circuit from the suprachiasmatic nucleus to DG drives cognitive impairment in migraine mice

Our research reveals a previously underappreciated GABAergic pathway from the SCN to the DG that is functionally implicated in cognitive deficits associated with migraine. The findings suggest that migraine is associated with altered recruitment of neuronal subpopulations and network-level coordination within the SCN and along the SCN-DG pathway. This is accompanied by increased recruitment of GABAergic interneurons in the DG and impaired DG information processing. Together, these results identify the SCN-DG circuit as a potential neuromodulatory target for future investigation of cognitive symptoms associated with migraine.