Sex differences in congenital hereditary endothelial dystrophy (CHED) and Slc4a11−/− mouse model of CHED
Male sex is associated with a more severe corneal phenotype in individuals with CHED and a Slc4a11<sup>-/-</sup> mouse model of the disease. Increased corneal edema in female Slc4a11<sup>-/-</sup> mice following gonadectomy suggests ovarian hormones play a protective role in maintaining corneal deturgescence in the setting of loss of SLC4A11 function.
Authors
- Matteo Pellegrini (ORCID: https://orcid.org/0000-0001-9355-9564)
- Muralidhar Ramappa (ORCID: https://orcid.org/0000-0003-3667-5483)
- Marco Morselli (ORCID: https://orcid.org/0000-0003-3351-5791)
- Jhuwala Venkatakrishnan (ORCID: https://orcid.org/0009-0007-9820-3306)
- Ananya Kaginalkar (ORCID: https://orcid.org/0000-0002-2722-0770)
- Arthur P. Arnold (ORCID: https://orcid.org/0000-0002-9908-9767)
- Eduardo Araujo
- Anthony John Aldave (ORCID: https://orcid.org/0000-0002-9082-4796)
- Saloni Gupta (ORCID: https://orcid.org/0000-0001-9436-4128)
- Wenlin Zhang (ORCID: https://orcid.org/0000-0003-3229-9177)
- R. K. Tandon
- Sunita Chaurasia
- Isa Matsubayashi
- Divya Sree Ramya
Institutions
- University of California, Los Angeles (US)
- L V Prasad Eye Institute (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1186/s13293-026-00879-9
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00