Single‐Cell RNA‐Sequencing Reveals Cachectic Satellite Cell Population in Muscle of Male Mice With Cancer Cachexia
We describe a novel satellite cell subcluster unique to cachexia. We also identified increased immune cell and fibroadipogenic progenitor content and decreased endothelial cell content that precede muscle wasting with cancer, suggesting a role for these cell populations in satellite cell dysfunction and muscle atrophy in this condition.
Authors
- Alex Brown (ORCID: https://orcid.org/0000-0003-3161-8172)
- Aisha Saleh
- Nadine Wiper‐Bergeron (ORCID: https://orcid.org/0000-0001-8448-3246)
- Michael De Lisio (ORCID: https://orcid.org/0000-0002-6462-2955)
- Nicolás Collao (ORCID: https://orcid.org/0000-0001-6293-4018)
- Natasha Strong
Institutions
- University of Ottawa (CA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1002/jcsm.70260
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00