OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism
Our findings identify a novel peripheral mechanism of opioid-induced itch mediated by OPRM1/MRGPRX1 heterodimers in sensory neurons. This receptor complex promotes calcium signaling and itch behavior, distinct from central or mast cell-dependent pathways. Targeting this heterodimer may offer new therapeutic strategies to alleviate opioid-induced itch without impairing analgesia.
Authors
- Babina Sanjel
- Kwang Won Jeong (ORCID: https://orcid.org/0000-0003-2258-8354)
- Diwas Rawal
- Wook-Joo Lee
- Won-Sik Shim
- Myeong Ryeo Kim
Institutions
- Gachon University (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1186/s12929-026-01238-x
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00