Towards precision antibiotic therapy: predictors and outcomes of meropenem target attainment

Three-quarters of the measurements achieved the PK/PD target of 100% fT>MIC, while half achieved the more stringent target of 100% fT>4×MIC, highlighting the need for optimised dosing strategies. Target achievement rates can be improved with therapeutic drug monitoring and personalised dosing approaches are needed.

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Publication Details

Journal
European Journal of Hospital Pharmacy
Published
2026-03-27
DOI
https://doi.org/10.1136/ejhpharm-2026-004940
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
0.00
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article

Towards precision antibiotic therapy: predictors and outcomes of meropenem target attainment

Eda Karadoğan, Esen Deniz Akman Ar, Murat Ozdede, Emre Kara et al.
European Journal of Hospital Pharmacy
Antibiotics Pharmacokinetics and Efficacy
article

Towards precision antibiotic therapy: predictors and outcomes of meropenem target attainment

Eda Karadoğan, Esen Deniz Akman Ar, Murat Ozdede, Emre Kara, Aslı Pınar, Gokhan Metan, Omrum Uzun
article en

Abstract

Three-quarters of the measurements achieved the PK/PD target of 100% fT>MIC, while half achieved the more stringent target of 100% fT>4×MIC, highlighting the need for optimised dosing strategies. Target achievement rates can be improved with therapeutic drug monitoring and personalised dosing approaches are needed.

European Journal of Hospital Pharmacy
Antalya IVF (TR), Hacettepe University (TR)
Zero hunger
Openalex Percentile: Top 4%
Antibiotics Pharmacokinetics and Efficacy
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