CD8 PET imaging with [ <sup>89</sup> Zr]Zr-berdoxam-crefmirlimab in patients with solid tumors: the Phase II iCorrelate study
We found a modest correlation between CD8 PET with [<sup>89</sup>Zr]Zr-berdoxam-crefmirlimab and intratumoral CD8 cell counts, likely because core needle biopsies do not fully represent the intratumoral heterogeneity of the CD8 cell distribution. Continued research is essential to evaluate in vivo CD8 PET signals, autoradiography, and CD8 T-cell presence by IHC in fully resected tumors. Further studies investigating the correlation between CD8 PET and immunotherapy outcomes are necessary to determine whether CD8 PET imaging could become a valuable tool for guiding immunotherapy development and informing clinical decision-making.
Authors
- Ronald L. Korn (ORCID: https://orcid.org/0000-0003-1141-5749)
- Kevin Maresca (ORCID: https://orcid.org/0000-0003-4420-1296)
- Agnish Dey (ORCID: https://orcid.org/0000-0003-0248-6764)
- Peter D. Zang (ORCID: https://orcid.org/0000-0002-5644-380X)
- Ian A. Wilson (ORCID: https://orcid.org/0000-0002-6469-2419)
- A. Mauguen
- Jacob Thomas (ORCID: https://orcid.org/0000-0002-8420-366X)
- Delphine L. Chen (ORCID: https://orcid.org/0000-0002-0150-5401)
- Gary A. Ulaner (ORCID: https://orcid.org/0000-0002-7953-0113)
- Guillaume Potdevin
- N. Pandit-Taskar
- Jonathan McConathy (ORCID: https://orcid.org/0000-0003-4681-2322)
- Alessandro Mascioni
- Edmund J. Keliher (ORCID: https://orcid.org/0000-0002-6607-0760)
- Kristin Schmiedehausen
- Michael M. Graham (ORCID: https://orcid.org/0000-0002-6374-4766)
- J Y Wong
- Kim Margolin (ORCID: https://orcid.org/0000-0002-5248-4356)
- Aman Singh
- Michael D. Farwell (ORCID: https://orcid.org/0000-0002-1041-7075)
- Guenter Schmidt
- Przemyslaw Twardowski
- Jayant Narang
- Fang Jia
- Anthony F. Shields
- F. Liu
- Michael Gordon
- Marcus O Butler
- David Hays
- Annick D Van den Abbeele
- Michael A. Postow
- Giuseppe Esposito
- Sumanta K. Pal
- William Le
- Michael R Ferris
Institutions
- University of Southern California (US)
- University of Iowa (US)
- City Of Hope National Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Pfizer (United States) (US)
- Georgetown University (US)
- University of Washington (US)
- Hospital of the University of Pennsylvania (US)
- University of Alabama System (US)
- MedStar Georgetown University Hospital (US)
- Princess Margaret Cancer Centre (CA)
- University of Alabama at Birmingham (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Massachusetts Medical Society (US)
- Saint John's Health Center (US)
- City of Hope (US)
- Southern California Clinical and Translational Science Institute (US)
- ImaginAb (United States) (US)
- USC Norris Comprehensive Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- HonorHealth (US)
- Takeda (United States) (US)
- AstraZeneca (United States) (US)
- Vitalant (US)
- Hoag Orthopedic Institute (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-012208
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00