Glucocorticoid-Induced alterations in DNA methylation in the H19 promoter of Bone Marrow-Derived Mesenchymal Stem Cells are associated with the pathogenesis of osteonecrosis
The Dnmt1/H19/GSK-3β axis reciprocally regulates BMSC osteogenic and adipogenic differentiation in GC-induced ONFH, representing a novel epigenetic mechanism underlying GC-induced ONFH and a promising MSC-based therapeutic strategy for early-stage disease.
Authors
- Song Gong
- Ruoyu Wang (ORCID: https://orcid.org/0000-0002-3644-1284)
- Jianzhong Guan (ORCID: https://orcid.org/0000-0002-5539-3978)
- Weihua Xu
- Shizhan Zhang (ORCID: https://orcid.org/0009-0003-8979-2269)
- Yong Feng
- Bo Wang
- Fei Du
- Jiangtao Liu
- Lu Zhang
- Lizhi Han
- Yang Wang
- Kun Nie
Institutions
- Union Hospital (HK)
- Bengbu Medical College (CN)
- Central Hospital of Wuhan (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1371/journal.pone.0345372
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00