Comparison of tissue acquisition techniques for Next-Generation Sequencing of non-small cell lung cancer (NSCLC)

Pleural fluid cell blocks and percutaneous image-guided pleural biopsies were least likely to be associated with successful NGS-based processing. Where possible, other sites for tissue acquisition should be considered in individuals with pleural disease to prevent delays in their pathway.

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Publication Details

Journal
BMJ Open Respiratory Research
Published
2026-03-01
DOI
https://doi.org/10.1136/bmjresp-2025-003793
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparison of tissue acquisition techniques for Next-Generation Sequencing of non-small cell lung cancer (NSCLC)

Amyn Bhamani, Lavanya Anandan, SB Naidu, Phil Bennett et al.
BMJ Open Respiratory Research
Lung Cancer Diagnosis and Treatment
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Comparison of tissue acquisition techniques for Next-Generation Sequencing of non-small cell lung cancer (NSCLC)

Amyn Bhamani, Lavanya Anandan, SB Naidu, Phil Bennett, Lucy Rogers, N Adroja, Ricky M. Thakrar, David Moore, Asia Ahmed, Neal Navani, Sam M Janes, Tanya Ahmad, Martin D Forster
article en

Abstract

Pleural fluid cell blocks and percutaneous image-guided pleural biopsies were least likely to be associated with successful NGS-based processing. Where possible, other sites for tissue acquisition should be considered in individuals with pleural disease to prevent delays in their pathway.

BMJ Open Respiratory ResearchVol. 13(1)
University College London Hospitals NHS Foundation Trust (GB), CRUK Lung Cancer Centre of Excellence (GB), Informa Healthcare (GB), University College London (GB)
Good health and well-being
Openalex Percentile: Top 4%
Lung Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Comparison of tissue acquisition techniques for Next-Generation Sequencing of non-small cell lung cancer (NSCLC) — Amyn Bhamani, Lavanya Anandan, et al. · BMJ Open Respiratory Research (2026) | TGRS Research Map | TGRS