Clinical Outcomes of Synthetic Absorbable Mesh Use in Breast Surgery: First Case Series in Reconstruction and Aesthetic Mastopexy

<h2>ABSTRACT</h2> Breast cancer remains one of the leading causes of female mortality worldwide, and mastectomy is often required as a therapeutic or prophylactic measure. Breast reconstruction plays a key role in restoring body symmetry and quality of life. Synthetic meshes have recently gained attention as adjuncts intended to provide additional soft-tissue support and assist in implant stabilization. Among these, the absorbable GORE® BIO-A® FS0915 has shown favorable results in soft tissue reconstructions, but its use in breast surgery has not been reported. This retrospective study included women who underwent breast reconstruction or mastopexy with implants and absorbable matrix between October 2022 and October 2024 at three hospitals in Americana, Brazil. Data were retrospectively collected and included demographic, clinical, surgical, and adjuvant treatment variables. Complications were classified as minor (not requiring reintervention) or major (requiring surgical management). Descriptive statistics were used to summarize the data. Thirty-eight patients (66 breasts) were included. Patient-level characteristics were analyzed per patient (n = 38), while surgical outcomes and complications were analyzed per breast (n = 66). The mean age was 47 years, and complications (per breast) were observed predominantly in older patients, those with multiple prior surgeries, and those exposed to radiotherapy or chemotherapy. Breast cancer was the main indication (79%), and no complications were observed in aesthetic-only cases. The overall complication rate was 19.7%, with 7.6% major (contracture, infection) and 12.1% minor (seroma, edema, rotation, dehiscence). In summary, the use of synthetic mesh in breast reconstruction and mastopexy was technically feasible and showed an acceptable preliminary safety profile within the context of this retrospective case series.