CXCR4+ cells in NPC tumor sphere have metastatic potential
A metastatic CSC subpopulation present in NPC express CXCR4 and have activated EMT and SDF-1/CXCR4-driven metastasis. CXCR4 may have utility as a biomarker and the SDF-1/CXCR4 axis may be a therapeutic target for NPC.
Authors
- Jingyu Li (ORCID: https://orcid.org/0000-0001-8400-0187)
- Yuan He
- Kaitai Yao
- Zhenwei Zhu
- Pei Guo
- Jingxian Liu
- Lin Chen
Institutions
- University of Science and Technology of China (CN)
- Sun Yat-sen University (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Brazilian Journal of Otorhinolaryngology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1016/j.bjorl.2026.101799
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00