Researchers in Canada support slow‐release morphine for treatment of OUD

In a comparison between slow‐release oral morphine (SROM) and methadone (which is by definition slow‐release), researchers in Canada measured dropout and mortality rates of both. They found that virtual patients on SROM were slightly more likely to discontinue treatment, but that the mortality risk for both medications was similar. They concluded that as long as measures to support retention are present, either medication may be appropriate for treatment for opioid use disorder (OUD).

Authors

Publication Details

Journal
Alcoholism & Drug Abuse Weekly
Published
2026-03-27
DOI
https://doi.org/10.1002/adaw.34855
Primary Topic
Opioid Use Disorder Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Researchers in Canada support slow‐release morphine for treatment of OUD

Alison Knopf
Alcoholism & Drug Abuse Weekly
Opioid Use Disorder Treatment
article

Researchers in Canada support slow‐release morphine for treatment of OUD

Alison Knopf
article en

Abstract

In a comparison between slow‐release oral morphine (SROM) and methadone (which is by definition slow‐release), researchers in Canada measured dropout and mortality rates of both. They found that virtual patients on SROM were slightly more likely to discontinue treatment, but that the mortality risk for both medications was similar. They concluded that as long as measures to support retention are present, either medication may be appropriate for treatment for opioid use disorder (OUD).

Alcoholism & Drug Abuse WeeklyVol. 38(13)
Good health and well-being
Openalex Percentile: Top 6%
Opioid Use Disorder Treatment
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Researchers in Canada support slow‐release morphine for treatment of OUD — Alison Knopf · Alcoholism & Drug Abuse Weekly (2026) | TGRS Research Map | TGRS