Comparable anal HPV burden and abnormal cytology in MSM using PrEP and MSM living with HIV: implications for screening and prevention

MSM using PrEP showed a burden of HR-HPV infection and abnormal anal cytology comparable to that observed in MSM living with HIV. These findings suggest that MSM-PrEP constitutes a high-risk group that may warrant reconsideration of current anal cancer screening strategies. The potential protective effect of postsexual-debut HPV vaccination merits further investigation.

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Publication Details

Journal
Sexually Transmitted Infections
Published
2026-03-27
DOI
https://doi.org/10.1136/sextrans-2025-056634
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparable anal HPV burden and abnormal cytology in MSM using PrEP and MSM living with HIV: implications for screening and prevention

Michel Verheyden, Jan Gutermuth, Marc Goossens, Sébastien Kindt et al.
Sexually Transmitted Infections
Cervical Cancer and HPV Research
article

Comparable anal HPV burden and abnormal cytology in MSM using PrEP and MSM living with HIV: implications for screening and prevention

Michel Verheyden, Jan Gutermuth, Marc Goossens, Sébastien Kindt, Shaira Sahebali, Sabine Allard, Yora Mostmans, Jason Brunetta, Magali Surmont
article en

Abstract

MSM using PrEP showed a burden of HR-HPV infection and abnormal anal cytology comparable to that observed in MSM living with HIV. These findings suggest that MSM-PrEP constitutes a high-risk group that may warrant reconsideration of current anal cancer screening strategies. The potential protective effect of postsexual-debut HPV vaccination merits further investigation.

Sexually Transmitted Infections
Université Libre de Bruxelles (BE), Vrije Universiteit Brussel (BE), Universitair Ziekenhuis Brussel (BE), Maple Leaf Medical Clinic (CA), Mathys (Netherlands) (NL)
Good health and well-being
Openalex Percentile: Top 6%
Cervical Cancer and HPV Research
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Comparable anal HPV burden and abnormal cytology in MSM using PrEP and MSM living with HIV: implications for screening and prevention — Michel Verheyden, Jan Gutermuth, et al. · Sexually Transmitted Infections (2026) | TGRS Research Map | TGRS