Clinical Improvements With Setmelanotide in a 2-Year-Old Patient With Hyperphagia and Obesity due to Leptin Receptor Deficiency: A Case Report

Setmelanotide treatment started in a 2-year-old patient and continued for 23 months led to reductions in hyperphagia and food-seeking behavior, as well as improved motor skill function, BMI, and blood lipids. These findings support the use of setmelanotide in young children with hyperphagia and obesity due to LEPR deficiency.

Authors

Publication Details

Journal
Obesity Facts
Published
2026-03-27
DOI
https://doi.org/10.1159/000551601
Primary Topic
Genetic and Kidney Cyst Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical Improvements With Setmelanotide in a 2-Year-Old Patient With Hyperphagia and Obesity due to Leptin Receptor Deficiency: A Case Report

Marina Gutiérrez Vilar, Mónica Ruiz Pons, Javier Merino Alonso, Alejandra Pérez Rodriguez
Obesity Facts
Genetic and Kidney Cyst Diseases
article

Clinical Improvements With Setmelanotide in a 2-Year-Old Patient With Hyperphagia and Obesity due to Leptin Receptor Deficiency: A Case Report

Marina Gutiérrez Vilar, Mónica Ruiz Pons, Javier Merino Alonso, Alejandra Pérez Rodriguez
article en

Abstract

Setmelanotide treatment started in a 2-year-old patient and continued for 23 months led to reductions in hyperphagia and food-seeking behavior, as well as improved motor skill function, BMI, and blood lipids. These findings support the use of setmelanotide in young children with hyperphagia and obesity due to LEPR deficiency.

Obesity Facts
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Openalex Percentile: Top 4%
Genetic and Kidney Cyst Diseases
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Clinical Improvements With Setmelanotide in a 2-Year-Old Patient With Hyperphagia and Obesity due to Leptin Receptor Deficiency: A Case Report — Marina Gutiérrez Vilar, Mónica Ruiz Pons, et al. · Obesity Facts (2026) | TGRS Research Map | TGRS