Stability of the translocator protein 18 kDa density within cognitive circuits in brains of virally-suppressed people with HIV
[11C]DPA-713 positron emission tomography (PET) has shown higher translocator protein (TSPO) availability, a marker of glial response, in cognitive control and declarative memory brain regions of virally suppressed people with HIV (VS-PWH). Here, 14 VS-PWH completed repeat TSPO PET after ~18 months. Regional TSPO was largely time-stable, with modest variability in some participants that was unrelated to antiretroviral therapy. Further study of a stable, higher TSPO density in select brain regions of VS-PWH is warranted.
Authors
- Il Minn (ORCID: https://orcid.org/0000-0002-7822-662X)
- Raha Maryam Dastgheyb (ORCID: https://orcid.org/0000-0002-4992-711X)
- Martin G. Pomper (ORCID: https://orcid.org/0000-0001-6753-3010)
- William B. Mathews (ORCID: https://orcid.org/0000-0001-8001-416X)
- Steven P. Rowe (ORCID: https://orcid.org/0000-0003-2897-4694)
- Wojciech G. Lesniak (ORCID: https://orcid.org/0000-0003-0734-4685)
- Jennifer M. Coughlin (ORCID: https://orcid.org/0000-0002-2514-9640)
- Pauline M. Maki (ORCID: https://orcid.org/0000-0002-8443-3430)
- Seble Kassaye (ORCID: https://orcid.org/0000-0002-7527-7384)
- Hwanhee Nam
- RF Dannals
- T.D. Brown
- Yong Du
- Leah H. Rubin
- Andrew W. Hall
- Michael Kassiou
Institutions
- The University of Sydney (AU)
- Bloomberg (United States) (US)
- Johns Hopkins University (US)
- Georgetown University (US)
- Johns Hopkins Medicine (US)
- University of Illinois Chicago (US)
- Southwestern Medical Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- AIDS
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1097/qad.0000000000004416
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00