One‐step generation of heritable mitochondrial <scp>DNA</scp> multiplex‐engineered rats using <scp>DddA</scp> ‐derived cytosine base editor
This work represents the first successful generation of heritable multi-site mtDNA mutant rats, providing a valuable model for elucidating the pathophysiological mechanisms of mitochondrial disorders and for developing potential therapeutics.
Authors
- Weining Kong (ORCID: https://orcid.org/0000-0002-6170-5704)
- Xiaolong Qi (ORCID: https://orcid.org/0000-0003-1468-9665)
- Bin Shen (ORCID: https://orcid.org/0000-0002-9794-6809)
- Lin Tan (ORCID: https://orcid.org/0000-0002-4921-1293)
- Shuo Pan (ORCID: https://orcid.org/0000-0002-1036-4890)
- N Liu
- Keru Li
- Gefan Wan
- Chenyang Liu
- Jie He
- Wei Chen
- Shan Gao
- Xu Zhang
- Wei Dong
- Yuanwu Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Laboratory Animal Science (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1002/ame2.70154
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00