AAV2-Retro–Mediated Gene Transfer Selectively Targets Outer Retinal Cells Following Intravitreal Injection
AAV2-retro enables efficient, outer retina-specific gene delivery following intravitreal administration. This approach overcomes the limitations of traditional intravitreal gene transfer and provides a minimally invasive alternative to subretinal injection. AAV2-retro-mediated transduction may facilitate preclinical studies of retinal degeneration and support the development of gene therapies aimed at preserving photoreceptors and RPE function.
Authors
- Chaimaa Kinane (ORCID: https://orcid.org/0009-0009-5089-4579)
- Kevin K. Park
- Pantelis Tsoulfas (ORCID: https://orcid.org/0000-0003-1974-6366)
- Venu Talla (ORCID: https://orcid.org/0000-0002-5695-7536)
- Moxa Panchal
Institutions
- University of Miami (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1167/iovs.67.3.54
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00