Results of the Pediatric Guideline Adherence and Outcomes (PEGASUS) Program Versus Usual Care Pragmatic Randomized Controlled Trial in Severe Traumatic Brain Injury

Implementing an evidence-based TBI program was not superior to usual care in increasing first 3-day cumulative ICU TBI guideline adherence rates in all children with severe TBI. However, implementation increased adherence rates in children with isolated severe TBI.

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Publication Details

Journal
Critical Care Medicine
Published
2026-03-27
DOI
https://doi.org/10.1097/ccm.0000000000007118
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
Type
article
Field-Weighted Citation Impact
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article

Results of the Pediatric Guideline Adherence and Outcomes (PEGASUS) Program Versus Usual Care Pragmatic Randomized Controlled Trial in Severe Traumatic Brain Injury

Bryan J. Weiner, Julia Velonjara, Nahuel Guadagnoli, Gustavo Petroni et al.
Critical Care Medicine
Traumatic Brain Injury and Neurovascular Disturbances
article

Results of the Pediatric Guideline Adherence and Outcomes (PEGASUS) Program Versus Usual Care Pragmatic Randomized Controlled Trial in Severe Traumatic Brain Injury

Bryan J. Weiner, Julia Velonjara, Nahuel Guadagnoli, Gustavo Petroni, Silvia Lujan, Charles Mock, for the Pediatric Guideline Adherence and Outcomes (PEGASUS) Argentina study group, Jin Wang, Monica S. Vavilala, Michael J. Bell
article en

Abstract

Implementing an evidence-based TBI program was not superior to usual care in increasing first 3-day cumulative ICU TBI guideline adherence rates in all children with severe TBI. However, implementation increased adherence rates in children with isolated severe TBI.

Critical Care Medicine
Apple (Israel) (IL), Children's National (US), Outcomes Research Consortium (US), University of Washington (US), National Institute of Neurological Disorders and Stroke (US), Harborview Injury Prevention and Research Center (US), Estudios Clínicos Latinoamérica (AR), Data Management (Italy) (IT)
Reduced inequalities
Openalex Percentile: Top 12%
Traumatic Brain Injury and Neurovascular Disturbances
DOISourceOpenAlex
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Results of the Pediatric Guideline Adherence and Outcomes (PEGASUS) Program Versus Usual Care Pragmatic Randomized Controlled Trial in Severe Traumatic Brain Injury — Bryan J. Weiner, Julia Velonjara, et al. · Critical Care Medicine (2026) | TGRS Research Map | TGRS