SRS43 - Assessing patient-reported quality of life outcomes after meningioma surgery using a condition-specific measure: a single centre study

Abstract Introduction Meningiomas are the most common primary intracranial tumour, yet evidence on long-term functional outcomes of surgical resection remains limited. Postoperative evaluations focus on radiological and oncological outcomes, often overlooking cognitive, emotional, and psychosocial sequelae. Many patients experience persistent deficits, including visual impairment, fatigue, sleep disruption and anxiety, despite clinical remission. As healthcare shifts towards patient-centred care, integrating the assessment of health-related quality of life (HRQOL) in the postoperative functional outcome is essential to improve surgical management of meningioma. The aim of this study was to characterise the postoperative HRQOL of patients who have undergone surgical resection of skull base meningiomas in a reference centre, intending to influence the National Anterior Skull Base Audit dataset. Methods The Meningioma Quality of Life (MQOL) questionnaire, a validated, condition-specific patient-reported outcome measure (PROM) was delivered via semi-structured telephone interviews. HRQOL, neurological deficits, and impairment patterns were assessed. Results 48 patients were included. MQOL scores were obtained for the week prior to surgery and the current time point. On average 8 of 9 domains deteriorated postoperatively, with 53% of patients reporting a net reduction in QOL. The mean change across domains was –0.29 (P = 0.036, d = 0.44) Conclusions To our knowledge, this marks the first use of disease-specific PROMs in the UK to evaluate postoperative HRQOL in meningioma. Early findings suggest that significant QOL impairments persist despite favourable surgical outcomes. Integration of PROMs like the MQOL into the anterior skull base audit dataset may help improve postoperative care and enhance preoperative counselling.