Brain Structure of South African Children Born to Mothers on Dolutegravir versus Efavirenz-Based Antiretroviral Therapy

Among this small sample of children at 3-4 years, statistically significant differences in global or regional brain structure were not detected between those exposed in the third trimester of pregnancy to DTG or EFV and CHU. Given the modest sample size, the study had limited power to detect small-to-moderate differences. Further longitudinal studies with larger sample sizes are needed to assess the effects of specific ART in the context of new regimens and better maternal HIV disease control, on CHEU brain structure.

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Publication Details

Journal
Journal of the Pediatric Infectious Diseases Society
Published
2026-03-27
DOI
https://doi.org/10.1093/jpids/piag022
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Brain Structure of South African Children Born to Mothers on Dolutegravir versus Efavirenz-Based Antiretroviral Therapy

Helene Theunissen, Catherine J. Wedderburn, Miriam Taegtmeyer, Nengjie He et al.
Journal of the Pediatric Infectious Diseases Society
HIV/AIDS drug development and treatment
article

Brain Structure of South African Children Born to Mothers on Dolutegravir versus Efavirenz-Based Antiretroviral Therapy

Helene Theunissen, Catherine J. Wedderburn, Miriam Taegtmeyer, Nengjie He, Catherine Orrell, Lucy Read, Helen Reynolds, Shirley Williams, Jessica E. Ringshaw, Jim Read, Kirsten A. Donald, Lauren Davel, Layla E. Bradford, Duolao Wang, Landon Myer, Niall J Bourke, Angela Colbers, Thokozile R Malaba, Catriona Waitt, Saye Khoo
article en

Abstract

Among this small sample of children at 3-4 years, statistically significant differences in global or regional brain structure were not detected between those exposed in the third trimester of pregnancy to DTG or EFV and CHU. Given the modest sample size, the study had limited power to detect small-to-moderate differences. Further longitudinal studies with larger sample sizes are needed to assess the effects of specific ART in the context of new regimens and better maternal HIV disease control, on CHEU brain structure.

Journal of the Pediatric Infectious Diseases Society
Desmond Tutu HIV Foundation (ZA), Radboud University Nijmegen (NL), University of Liverpool (GB), University of Cape Town (ZA), Wellcome Centre for Human Neuroimaging (GB), King's College London (GB), Liverpool School of Tropical Medicine (GB), University Medical Center (US), Radboud University Medical Center (NL), Neuroscience Institute (IT), Infectious Diseases Institute (UG), Makerere University (UG)
Good health and well-being
Openalex Percentile: Top 6%
HIV/AIDS drug development and treatment
DOIOpen Access PDFOpenAlex
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