Emergence of KPC-producing <i>Pseudomonas aeruginosa</i> in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam

We report an outbreak of KPC-producing <i>Pseudomonas aeruginosa</i> in Spain, involving four patients and an environmental isolate recovered from a hospital sink. All isolates belonged to clone ST253 and exhibited difficult-to-treat resistance, including resistance to imipenem/relebactam and meropenem/vaborbactam. Genomic analysis confirmed a plasmid-encoded <i>bla</i><sub>KPC-2</sub> and OprD deficiency. Functional assays demonstrated synergy between KPC-2 production and porin loss on resistance to carbapenem/β-lactamase inhibitors. The findings highlight the clinical threat posed by KPC-producing <i>P. aeruginosa</i>.

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Publication Details

Journal
Antimicrobial Agents and Chemotherapy
Published
2026-03-27
DOI
https://doi.org/10.1128/aac.01657-25
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
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article

Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam

Biel Taltavull, Salud Rodríguez-Pallares, Alejandro Beceiro, Tania Blanco-Martín et al.
Antimicrobial Agents and Chemotherapy
Antibiotic Resistance in Bacteria
article

Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam

Biel Taltavull, Salud Rodríguez-Pallares, Alejandro Beceiro, Tania Blanco-Martín, Jorge Arca-Suárez, Miriam Moscoso, Lucía González-Pinto, María Tarriño-León, Lucía Sánchez-Peña, Gloria Pérez-Rodríguez, María del Mar Gallardo-García, Germán Bou, Pablo Aja-Macaya, Antonio Oliver
article en

Abstract

We report an outbreak of KPC-producing <i>Pseudomonas aeruginosa</i> in Spain, involving four patients and an environmental isolate recovered from a hospital sink. All isolates belonged to clone ST253 and exhibited difficult-to-treat resistance, including resistance to imipenem/relebactam and meropenem/vaborbactam. Genomic analysis confirmed a plasmid-encoded <i>bla</i><sub>KPC-2</sub> and OprD deficiency. Functional assays demonstrated synergy between KPC-2 production and porin loss on resistance to carbapenem/β-lactamase inhibitors. The findings highlight the clinical threat posed by KPC-producing <i>P. aeruginosa</i>.

Antimicrobial Agents and Chemotherapy
Universidade da Coruña (ES), Instituto de Salud Carlos III (ES), Hospital Universitario Virgen de las Nieves (ES), Health Research Institute of the Balearic Islands (ES), Hospital Universitario Son Espases (ES), Instituto de Investigación Biomédica de A Coruña (ES)
Openalex Percentile: Top 6%
Antibiotic Resistance in Bacteria
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