Reduced cytochrome P-450 (CYP) 2D6 activity and Plasmodium vivax malaria risk in Amazonians: A retrospective, population-based cohort study
Amazonians with an AS ≤ 0.25, but not necessarily those with intermediate CYP2D6 activity, have a greater risk of recurrence after a PQ-treated P. vivax infection and require alternative relapse suppression regimens for the radical cure of vivax malaria.
Authors
- Carlos A. Prete (ORCID: https://orcid.org/0000-0002-3907-423X)
- Igor Cavallini Johansen (ORCID: https://orcid.org/0000-0002-5360-3740)
- Maria Carolina S. B. Puça
- Winni A. Ladeia
- on behalf of the Mâncio Lima Cohort Study Working Group
- Rodrigo M. Corder
- Tais Nobrega de Sousa
- Marcelo U. Ferreira
- Priscila T. Rodrigues
Institutions
- University of London (GB)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Karolinska Institutet (SE)
- Brazilian Center for Research in Energy and Materials (BR)
- Imperial College London (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1371/journal.pntd.0014160
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00