Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice

This study highlights the real-world effectiveness and safety of cenobamate, either as monotherapy (after conversion from polytherapy) or in dual therapy, in patients with drug-resistant epilepsy. Cenobamate allows for a significant treatment simplification, resulting in fewer treatment-related adverse events without compromising seizure reduction.

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Publication Details

Journal
Epileptic Disorders
Published
2026-03-27
DOI
https://doi.org/10.1002/epd2.70222
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice

Yolanda López-Moreno, José Carlos Estévez María, Guillermina García Martín, Dulce Campos Blanco et al.
Epileptic Disorders
Epilepsy research and treatment
article

Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice

Yolanda López-Moreno, José Carlos Estévez María, Guillermina García Martín, Dulce Campos Blanco, María Isabel Chamorro Muñoz, A Fernández-Cabrera, P. Martínez García, Raquel Calle, Estuardo Daniel Castro Ruiz, Sergio Navarro Conti, Isabel Ros González, Irene Lorite Fuentes, Álvaro Sánchez‐Guijo Benavente, Pedro Jesús Serrano Castro
article en

Abstract

This study highlights the real-world effectiveness and safety of cenobamate, either as monotherapy (after conversion from polytherapy) or in dual therapy, in patients with drug-resistant epilepsy. Cenobamate allows for a significant treatment simplification, resulting in fewer treatment-related adverse events without compromising seizure reduction.

Epileptic Disorders
Hospital Regional Universitario de Málaga (ES), Instituto de Investigación Biosanitaria de Granada (ES), Complejo Hospitalario de Jaén (ES), Hospital Universitario Reina Sofía (ES), Hospital Universitario Lucus Augusti (ES), Hospital Clínico Universitario Virgen de la Victoria (ES), Hospital Clínico Universitario de Valladolid (ES), Instituto de Investigación Biomédica de Málaga (ES), Universidad de Málaga (ES)
Peace, Justice and strong institutions
Openalex Percentile: Top 13%
Epilepsy research and treatment
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Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice — Yolanda López-Moreno, José Carlos Estévez María, et al. · Epileptic Disorders (2026) | TGRS Research Map | TGRS