Design and implementation of a novel integrated timing and fast protection system for in-hospital AB-BNCT

Accelerator-based boron neutron capture therapy (AB-BNCT) necessitates highly reliable timing and rapid protection systems with minimal latency to ensure safe and synchronized operation. Conventional clinical accelerator control architectures; however, are often characterized by fragmented subsystems, excessive signal delays, and insufficient integration of timing, protection, and device control functions. To address these challenges, we introduce a unified hardware architecture specifically designed for AB-BNCT. This system integrates device control, timing, and fast protection into a single standardized platform using a custom reverse backplane that provides direct, low-latency data paths. Such a centralized design eliminates redundant interconnections, reduces end-to-end propagation delay, and enhances real-time responsiveness. Precise measurements indicate that the core protection logic responds in under 500 ns, excluding interlock-communication latency, thereby establishing a new benchmark for medical accelerator safety systems. Additionally, an intelligent beam-operation and shutdown mechanism is complemented to dynamically optimize beam delivery while ensuring fail-safe termination under fault conditions. This work offers three key contributions: First, it introduces the first integrated hardware platform tailored for AB-BNCT; second, it demonstrates record-low protection latency validated by metrology-grade testing; and last, it presents a safety-aware beam-control strategy that integrates real-time protection with clinical workflow stability. The proposed architecture significantly enhances the reliability, efficiency, and clinical feasibility of next-generation AB-BNCT facilities.

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Publication Details

Journal
Nuclear Engineering and Technology
Published
2026-03-27
DOI
https://doi.org/10.1016/j.net.2026.104279
Primary Topic
Boron Compounds in Chemistry
Type
article
Field-Weighted Citation Impact
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article

Design and implementation of a novel integrated timing and fast protection system for in-hospital AB-BNCT

Kangjia Xue, D. P. Jin, Zhiping Li, Linyan Rong et al.
Nuclear Engineering and Technology
Boron Compounds in Chemistry
article

Design and implementation of a novel integrated timing and fast protection system for in-hospital AB-BNCT

Kangjia Xue, D. P. Jin, Zhiping Li, Linyan Rong, Xuan Wu, Yongcheng He, Peng Zhu, Zhencheng Mu, Huafu Ouyang, Yuliang Zhang, Mingtao Li, Lin Wang
article en

Abstract

Accelerator-based boron neutron capture therapy (AB-BNCT) necessitates highly reliable timing and rapid protection systems with minimal latency to ensure safe and synchronized operation. Conventional clinical accelerator control architectures; however, are often characterized by fragmented subsystems, excessive signal delays, and insufficient integration of timing, protection, and device control functions. To address these challenges, we introduce a unified hardware architecture specifically designed for AB-BNCT. This system integrates device control, timing, and fast protection into a single standardized platform using a custom reverse backplane that provides direct, low-latency data paths. Such a centralized design eliminates redundant interconnections, reduces end-to-end propagation delay, and enhances real-time responsiveness. Precise measurements indicate that the core protection logic responds in under 500 ns, excluding interlock-communication latency, thereby establishing a new benchmark for medical accelerator safety systems. Additionally, an intelligent beam-operation and shutdown mechanism is complemented to dynamically optimize beam delivery while ensuring fail-safe termination under fault conditions. This work offers three key contributions: First, it introduces the first integrated hardware platform tailored for AB-BNCT; second, it demonstrates record-low protection latency validated by metrology-grade testing; and last, it presents a safety-aware beam-control strategy that integrates real-time protection with clinical workflow stability. The proposed architecture significantly enhances the reliability, efficiency, and clinical feasibility of next-generation AB-BNCT facilities.

Nuclear Engineering and TechnologyVol. 58(7)
Chinese Academy of Sciences (CN), China Spallation Neutron Source (CN), Institute of High Energy Physics (CN), University of Chinese Academy of Sciences (CN)
Openalex Percentile: Top 5%
Boron Compounds in Chemistry
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