A Comparative Experimental Study Of Healing Effect Of Different Oral Wound Dresssings For Oral Ulcers

Objectives: Wound dressings protect the wound and accelerate the healing of ulcers. This study was designed to assess the impact of distinct the impact of oral dressings for the wound healing phase of experimentally produced traumatic oral ulcers.Materials and Methods: The study included 45 male Sprague-Dawley rats, which were randomly allocated into three groups: Group 1, Group 2 and Control Group.Two different wound dressings were applied: hyaluronic acid (Group 1) and a wound dressing composed of a combination of bioactive materials (Group 2). Tissue samples were taken in the 3rd, 7th,14th days and evaluated histopathologically. The Kruskal–Wallis test was applied to compare numerical data across groups, followed by post-hoc testing to identify intergroup differences. Categorical variables were compared using the Chi-square test.Results: Group 1 exhibited enhanced overall efficacy, with a notable decrease in ulceration recorded on days 3, 7, and 14 in Group 2. Edema was more noticeable in Group 2 than in Group 1. Group 2 revealed superior efficacy in facilitating granulation tissue production in early phase. Both groups demonstrated enhanced migration of polymorphonuclear leukocytes and mononuclear cells to the ulcer location. Conclusions: Both wound coverings positively affected the wound healing process by regulating distinct phases of healing.