Reproductive tissue–derived stromal cells rescue fertility by coupling follicular activation with endometrial remodeling

These data suggest that MSCs derived from reproductive tissues, particularly endometrial origin, may restore fertility in POI by linking follicular activation to endometrial remodeling and support the translational development of MSC therapies that address both follicular depletion and uterine competence in infertility.

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Publication Details

Journal
Stem Cells Translational Medicine
Published
2026-03-23
DOI
https://doi.org/10.1093/stcltm/szag013
Primary Topic
Reproductive Biology and Fertility
Type
article
Field-Weighted Citation Impact
0.00
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article

Reproductive tissue–derived stromal cells rescue fertility by coupling follicular activation with endometrial remodeling

Rūta Navakauskienė, Elvina Valatkaitė, Veronika Viktorija Borutinskaitė, Aistė Zentelytė-Vilkė et al.
Stem Cells Translational Medicine
Reproductive Biology and Fertility
article

Reproductive tissue–derived stromal cells rescue fertility by coupling follicular activation with endometrial remodeling

Rūta Navakauskienė, Elvina Valatkaitė, Veronika Viktorija Borutinskaitė, Aistė Zentelytė-Vilkė, Indrė Krastinaitė
article en

Abstract

These data suggest that MSCs derived from reproductive tissues, particularly endometrial origin, may restore fertility in POI by linking follicular activation to endometrial remodeling and support the translational development of MSC therapies that address both follicular depletion and uterine competence in infertility.

Stem Cells Translational MedicineVol. 15(4)
Vilnius University (LT)
Zero hunger
Openalex Percentile: Top 7%
Reproductive Biology and Fertility
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