Forkhead box protein M1 network induction and crosstalk drives the development of alcohol-associated liver disease
Taken together, FOXM1 is activated in hepatocytes in response to EtOH through a mechanism that involves PKCε, MEK/ERK, cyclin D1-CDK4/6, PIN1, and GRN. Targeting this pathway may represent a novel therapeutic strategy for ALD.
Authors
- Takashi Tsuchiya (ORCID: https://orcid.org/0000-0003-2594-1811)
- Shelly Chi-Loo Lu (ORCID: https://orcid.org/0000-0003-2128-5407)
- Liqing Lu (ORCID: https://orcid.org/0000-0001-7420-0548)
- Jiaohong Wang
- G Zhang
- Brent Beadell (ORCID: https://orcid.org/0000-0003-0396-6639)
- Maria Lauda Tomasi (ORCID: https://orcid.org/0000-0001-8156-9052)
- Jyoti Chhimwal (ORCID: https://orcid.org/0000-0002-6155-7721)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Sonal Sinha
- Bing Yang
- Heping Yang
- Ting Liu
- Lucía Barbier-Torres
Institutions
- Cedars-Sinai Medical Center (US)
- Central South University (CN)
- Guangxi Medical University (CN)
- Ministry of Education (SA)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Xiangya Hospital Central South University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1097/hep.0000000000001753
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00