Investigation of TRPM8 Gene Variations in A Turkish Population with Migraine

Objective: A migraine is a type of headache that occurs in attacks. The rs10166942 single-nucleotide polymorphism (SNP) in the eighth member of the subfamily melastin of the potential transition receptor channel (transient receptor potential cation channel, subfamily M, member 8) (TRPM8) genes is thought to play a role in the etiology of migraine. Migraine shares certain characteristics with neuropathic pain, and TRPM8 has been identified as a potential target for treating neuropathic pain in animal models.This study aimed to determine the frequency of TRPM8 polymorphisms and their association with migraine in a Turkish population.Methods: The study included 68 unrelated migraine patients and 59 healthy individuals as the control group. The TRPM8 rs10166942 gene polymorphism was identified using the Real Time Polymerase Chain Reaction Melting Curve Analysis system.Results: A significant difference in the TRPM8 rs10166942 variant was observed between migraine patients and controls. The TRPM8 genotype distribution differed significantly in the patient group (TT=72 %; TC=26.4%; CC=1.5 %) and control group (TT=64.4 %; TC=25.4 %; CC=10.2 %). In the control and migraine patient groups, the frequencies of the C and T alleles were 22.8% and 77.1%, respectively, and 14.7% and 85.3%, respectively.Conclusion: The TRPM8 rs10166942 gene polymorphism was found to be associated with migraine in female patients in the Turkish population.