Transition‐Metal‐Free LiO <i> <sup>t</sup> </i> Bu‐Promoted Three‐Component Reaction for Efficient Synthesis of Triazolyl (Thio)ureas
ABSTRACT A transition‐metal‐free LiO t Bu‐promoted three‐component reaction for efficient synthesis of the triazolyl (thio)ureas has been reported. This reaction proceeded via the cyclocondensation of nitriles and azides in the presence of a base, followed by the interception of the triazolamine and triazole nitrogen anion intermediate using (thio)carbamoylimidazoles. This method is characterized by being transition‐metal‐free, a broad substrate scope, and mild reaction conditions.
Authors
- W. J. Wang
- Chunpeng Qiu
- Younan Wang
- Zhihao Zuo
- Jingyu Wang
Institutions
- Qufu Normal University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1002/ajoc.70375
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00