PET/CT imaging-based quantification of respiratory tract deposition of small- and large-particle aerosols versus intranasal bolus in rodents
PET/CT imaging-based quantification enabled novel characterization of particle deposition in rodents and supports an inverse relationship between aerodynamic particle size and pulmonary deposition. The regional distribution of intranasal bolus administered FDG more closely resembled large-particle aerosols than small-particle aerosols. These findings may aid in understanding the infectivity and pathogenicity of bioaerosols based on particle size and raise concern about substituting intranasal administration for aerosol exposure.
Authors
- Jeremy A. Boydston (ORCID: https://orcid.org/0000-0002-2740-2507)
- Ian Crozier (ORCID: https://orcid.org/0000-0003-4652-7791)
- Paul Dabisch (ORCID: https://orcid.org/0000-0002-3181-6825)
- Gerald Godwin
- Claudia Calcagno (ORCID: https://orcid.org/0000-0002-4325-8728)
- Rebecca Reeder (ORCID: https://orcid.org/0009-0005-1927-1155)
- J. Kyle Bohannon (ORCID: https://orcid.org/0000-0003-1096-1393)
- Christopher Bartos
- Matthew G. Lackemeyer (ORCID: https://orcid.org/0000-0002-2174-9630)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Jens Kuhn
- Russ Byrum
- Kurt Cooper
- Kathryn Conway
- Nicholas Vaughan
- Venkatesh Mani
- William Kendall
- Kristi Partner
- Steve Mazur
- Yu Cong
Institutions
- Frederick National Laboratory for Cancer Research (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Inhalation Toxicology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1080/08958378.2026.2648617
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00