Emergence and Genomic Characterization of a Hypervirulent <i>Klebsiella pneumoniae</i> Isolate From a New Clone in Brazil

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community-acquired and healthcare-associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest country, remain lacking. We performed a retrospective and prospective large-scale surveillance of clinical, veterinary, and community isolates to identify hypervirulent and resistant K. pneumoniae. Among 1,008 isolates screened, one strain (ID_074_25) met hvKp criteria, displaying key virulence loci. Whole-genome sequencing confirmed its genomic features, including a novel sequence type and a novel cluster in NCBI Pathogen Detection tool. This study underscores the need for national surveillance and capacity-building in reference laboratories.

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Publication Details

Journal
Microbiology and Immunology
Published
2026-03-27
DOI
https://doi.org/10.1111/1348-0421.70052
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
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article

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Cláudio Tavares Sacchi, Karoline Rodrigues Campos, Patrik Junior de Lima Paz, Pedro Smith Pereira Ferraro et al.
Microbiology and Immunology
Antibiotic Resistance in Bacteria
article

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Cláudio Tavares Sacchi, Karoline Rodrigues Campos, Patrik Junior de Lima Paz, Pedro Smith Pereira Ferraro, Amanda Maria de Jesus Bertani, Geraldine Madalosso, Jorge Siguemassa Higa, Andréia Rodrigues de Souza, Denise Brandão de Assis, Carlos Henrique Camargo, Amanda Yaeko Yamada, Ana Beatriz Nascimento Costa, Rafaela Mastrangelo Rissetti, Maria Solange Duarte Soares, Marlon Benedito Nascimento Santos, Márcio García Ribeiro, Christiane Salvador, Monique Ribeiro Tiba‐Casas, Giovanna de Pinho Pieri, Carolina Lechinski de Paula, Daniel de Sena Miranda, Daniela dos Santos Souza
article en

Abstract

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community-acquired and healthcare-associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest country, remain lacking. We performed a retrospective and prospective large-scale surveillance of clinical, veterinary, and community isolates to identify hypervirulent and resistant K. pneumoniae. Among 1,008 isolates screened, one strain (ID_074_25) met hvKp criteria, displaying key virulence loci. Whole-genome sequencing confirmed its genomic features, including a novel sequence type and a novel cluster in NCBI Pathogen Detection tool. This study underscores the need for national surveillance and capacity-building in reference laboratories.

Microbiology and Immunology
Universidade de São Paulo (BR), Instituto Adolfo Lutz (BR), Governo do Estado de São Paulo (BR), Instituto de Saúde (BR), Secretaria da Saúde (BR), Faculdade de Medicina do ABC (BR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Universidade Estadual Paulista (Unesp) (BR)
Openalex Percentile: Top 6%
Antibiotic Resistance in Bacteria
DOIOpen Access PDFOpenAlex
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