Spectrum of Germline Cytogenomic Alterations in <i>RB1</i> in Mexican Patients With Retinoblastoma
This study provides an overview of the spectrum of germline cytogenetic alterations and clinical features in Mexican patients with RB. Our results expand the understanding of RB in this population and underscore the need for multimodal approaches for the detection and functional characterization of RB1 alterations. This study reports the largest Mexican retinoblastoma cohort with comprehensive germline RB1 characterization and high detection rates, particularly in bilateral disease.
Authors
- Katia Alejandra Castillo‐Reyes
- Mireya Orozco‐Vela (ORCID: https://orcid.org/0009-0005-2701-1281)
- Jorge Román Corona‐Rivera (ORCID: https://orcid.org/0000-0002-4626-148X)
- Aurea Márquez‐Mora
- Sinhué Alejandro Brukman‐Jiménez (ORCID: https://orcid.org/0000-0002-2715-7003)
- Lucina Bobadilla‐Morales (ORCID: https://orcid.org/0000-0002-7035-7924)
- Alfredo Corona‐Rivera
- Juan Antonio Ramirez‐Corona
- Jose de Jesus Pérez‐Becerra
- Graciela Serafin‐Saucedo
- Uriel Francisco Santana‐Bejarano
- Graciela Gonzalez‐Perez
- Violeta Cassandra Vera‐Cuevas
Institutions
- Universidad Autónoma de la Ciudad de México (MX)
- Universidad de Guadalajara (MX)
- Hospital Civil de Guadalajara (MX)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1002/1545-5017.70267
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00