Comparative Analysis of Four Matrix Dilution Methods for Eliminating <scp>IgM</scp> Paraprotein Interference in Prealbumin and Uric Acid Assays: Based on Two Case Reports
Effective elimination of IgM paraprotein interference requires assay-specific pretreatment strategies. PEG-based dilution is optimal for PA immunoturbidimetric assays, while osmotic modulation with hypertonic saline is most effective for UA measurement. Deionized water dilution provides a practical, broadly applicable alternative. These simple protocols are suitable for routine clinical laboratory implementation.
Authors
- Denglu Zhang (ORCID: https://orcid.org/0000-0001-8557-457X)
- Xiaowei Chi
- Weifang Liu
- Huihui Jiang
- Zihan Liu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- University of Washington (US)
- University of Washington Applied Physics Laboratory (US)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1002/jcla.70209
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00