Analysis of the Phenotype and Gene Mutations of Two Families With Combined Mutations of Anticoagulant Protein Genes

In both pedigrees, we identified two distinct mutations in AT and PC. Dual mutations in SERPINC1 and PROC confer markedly increased VTE susceptibility.

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Publication Details

Journal
Molecular Genetics & Genomic Medicine
Published
2026-03-26
DOI
https://doi.org/10.1002/mgg3.70191
Primary Topic
Blood Coagulation and Thrombosis Mechanisms
Type
article
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0.00
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article

Analysis of the Phenotype and Gene Mutations of Two Families With Combined Mutations of Anticoagulant Protein Genes

Yan Guo, Wanzhong Kong, T T Shan, W J Y Zheng et al.
Molecular Genetics & Genomic Medicine
Blood Coagulation and Thrombosis Mechanisms
article

Analysis of the Phenotype and Gene Mutations of Two Families With Combined Mutations of Anticoagulant Protein Genes

Yan Guo, Wanzhong Kong, T T Shan, W J Y Zheng, C Zhao, Xiaojing Zou
article en

Abstract

In both pedigrees, we identified two distinct mutations in AT and PC. Dual mutations in SERPINC1 and PROC confer markedly increased VTE susceptibility.

Molecular Genetics & Genomic MedicineVol. 14(4)
Wenzhou Medical University (CN), Wenzhou Hospital of Traditional Chinese Medicine (CN)
Zero hunger
Openalex Percentile: Top 4%
Blood Coagulation and Thrombosis Mechanisms
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