Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected
HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023-0.19] among infants with LBW and 0.018 (IQR 0.010-0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.
Authors
- Andrea L. Conroy (ORCID: https://orcid.org/0000-0002-5328-6511)
- Michael Hawkes (ORCID: https://orcid.org/0000-0002-4122-0937)
- Jeanne Brochon
- Julia Sawatzky
- Robert Opoka
- Fatima Kakkar
- Sophie Namasopo
- Jason Brophy
Institutions
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- Children's Hospital of Eastern Ontario (CA)
- Kabale Hospital (UG)
- Mulago Hospital (UG)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Makerere University (UG)
Publication Details
- Journal
- AIDS
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1097/qad.0000000000004424
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00