Survival Then and Now in Patients With Surgically Resected Brain Metastasis: Major Improvement in Cases With Controlled Primary Tumor

Patients with resected and postoperatively irradiated brain metastasis benefited from additional systemic therapy. Only one subgroup experienced major survival prolongation in more recent years: those with controlled primary tumor. Therefore, efforts to optimize primary tumor control, such as surgery and radical radiotherapy, may play an important role in multimodal treatment paradigms.