Phase I Study of Mosperafenib, a Novel Paradox Breaker B-Raf Proto-Oncogene Serine/Threonine Kinase (BRAF) Inhibitor, in Patients With <i>BRAF</i> V600-Mutant Solid Tumors

Mosperafenib demonstrated a favorable safety profile, sustained target inhibition, and early signs of clinically meaningful single-agent activity in BRAFi-naïve and BRAFi-exposed patients.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2026-03-27
DOI
https://doi.org/10.1200/jco-25-02444
Primary Topic
Melanoma and MAPK Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

Phase I Study of Mosperafenib, a Novel Paradox Breaker B-Raf Proto-Oncogene Serine/Threonine Kinase (BRAF) Inhibitor, in Patients With BRAF V600-Mutant Solid Tumors

Gabriel Schnetzler, María Vieito, Oliver Edgar Bechter, Florian Renner et al.
Journal of Clinical Oncology
Melanoma and MAPK Pathways
article

Phase I Study of Mosperafenib, a Novel Paradox Breaker B-Raf Proto-Oncogene Serine/Threonine Kinase (BRAF) Inhibitor, in Patients With BRAF V600-Mutant Solid Tumors

Gabriel Schnetzler, María Vieito, Oliver Edgar Bechter, Florian Renner, Elisa Cinato, I. Moreno, Nicole A. Kratochwil, E. Fontana, Nino Keshelava, Christina Godfried Sie, Nick Flinn, David Dejardin, Andreas Roller, Catherine Han, Martin Kornacker, Piergiorgio Pettazzoni, R. Plummer, H. Prenen, Ernesto Guarin, Eduardo Castañón, Tomi Fakolade, Rikke Løvendahl Eefsen, Martha Serrano-Serrano, Reinhard Dummer, Abiraj Keelara, David J. Pinato, Mahdi About
article en

Abstract

Mosperafenib demonstrated a favorable safety profile, sustained target inhibition, and early signs of clinically meaningful single-agent activity in BRAFi-naïve and BRAFi-exposed patients.

Journal of Clinical Oncology
Roche (Switzerland) (CH), Universitat Autònoma de Barcelona (ES), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), Sarah Cannon Research Institute (GB), Auckland City Hospital (NZ), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Hammersmith Hospital (GB), Gentofte Hospital (DK), University Hospital of Zurich (CH), Antwerp University Hospital (BE), Roche (United Kingdom) (GB), HM Hospitales (ES), Clinica Universidad de Navarra (ES), Hospital Universitario HM Sanchinarro (ES), Imperial College London (GB)
Good health and well-being
Openalex Percentile: Top 6%
Melanoma and MAPK Pathways
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