Phase I Study of Mosperafenib, a Novel Paradox Breaker B-Raf Proto-Oncogene Serine/Threonine Kinase (BRAF) Inhibitor, in Patients With <i>BRAF</i> V600-Mutant Solid Tumors
Mosperafenib demonstrated a favorable safety profile, sustained target inhibition, and early signs of clinically meaningful single-agent activity in BRAFi-naïve and BRAFi-exposed patients.
Authors
- Gabriel Schnetzler (ORCID: https://orcid.org/0000-0003-4889-8596)
- María Vieito (ORCID: https://orcid.org/0000-0001-7531-343X)
- Oliver Edgar Bechter (ORCID: https://orcid.org/0000-0003-0667-3284)
- Florian Renner (ORCID: https://orcid.org/0000-0003-3326-0303)
- Elisa Cinato
- I. Moreno
- Nicole A. Kratochwil (ORCID: https://orcid.org/0000-0002-2149-4375)
- E. Fontana
- Nino Keshelava (ORCID: https://orcid.org/0009-0001-0978-3393)
- Christina Godfried Sie (ORCID: https://orcid.org/0000-0001-6377-4255)
- Nick Flinn
- David Dejardin (ORCID: https://orcid.org/0000-0001-8960-5345)
- Andreas Roller (ORCID: https://orcid.org/0000-0001-6335-0962)
- Catherine Han (ORCID: https://orcid.org/0000-0003-1016-3113)
- Martin Kornacker (ORCID: https://orcid.org/0000-0002-3502-928X)
- Piergiorgio Pettazzoni (ORCID: https://orcid.org/0000-0001-9039-2463)
- R. Plummer
- H. Prenen
- Ernesto Guarin
- Eduardo Castañón
- Tomi Fakolade
- Rikke Løvendahl Eefsen
- Martha Serrano-Serrano
- Reinhard Dummer
- Abiraj Keelara
- David J. Pinato
- Mahdi About
Institutions
- Roche (Switzerland) (CH)
- Universitat Autònoma de Barcelona (ES)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Sarah Cannon Research Institute (GB)
- Auckland City Hospital (NZ)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- Gentofte Hospital (DK)
- University Hospital of Zurich (CH)
- Antwerp University Hospital (BE)
- Roche (United Kingdom) (GB)
- HM Hospitales (ES)
- Clinica Universidad de Navarra (ES)
- Hospital Universitario HM Sanchinarro (ES)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1200/jco-25-02444
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00