SRS65 - Trends in diverticular disease mortality among United States adults (1999–2020) by gender, race, and geographic region

Abstract Background Diverticular disease of the intestine is a major gastrointestinal cause of mortality in the United States and the world. Aim To identify mortality trends of diverticular disease among adults in the United States, examining regional and demographic variations. Methods The mortality data were extracted as age-adjusted mortality rates (AAMRs) from the CDC WONDER database using ICD-10 codes K57.0 to K57.9 from 1999 to 2020 in adults ≥45 years of age. These AAMRs were stratified by gender, ethnicity, and demographics and analyzed using Joinpoint regression to determine annual percent changes (APCs). Results Between 1999 and 2020, 114 044 deaths were reported. Our analysis reports a progressive decline in mortality with AAMR decreasing from 6.7 in 1999 to 6.1 in 2003 (APC: −2.60), declining further to 3.6 in 2013 (APC: −5.16), with a minimal decrease to 3.5 in 2020 (APC: −0.65). Women consistently had a higher AAMR (4.8) than men (3.8). The racial analysis reported the highest overall AAMR in NH Whites (4.7), followed by NH African Americans (3.9), Hispanics (3.1), and NH Asians (1.5), with unreliable data for the NH American Indians. States, such as Wyoming and Vermont, reported the highest mortality compared to others. Regional analysis showed AAMR was higher in the Midwest and West regions (4.7) compared to the Northeast and South regions (4.2), and higher in nonmetropolitan areas (5.4) compared to metropolitan areas (4.2). Conclusions Although the annual mortality of diverticular disease has decreased since 1999, certain demographic and regional disparities warrant further research to plan appropriate interventions.