Parallel regulation of goblet cell–associated antigen passages by reduced microbial sensing and mAChR4 signaling in Muc2 deficiency prevents ethanol-induced liver injury
GAPs are central to gut-liver homeostasis. Mucin-2 deficiency enhances GAP formation and confers protection against ALD, whereas GAP closure exacerbates disease. Targeting GC-specific mAChR4 to restore GAPs represents a promising therapeutic strategy for ALD.
Authors
- Álvaro Eguileor (ORCID: https://orcid.org/0000-0002-0302-6762)
- Susan Mayo
- Noemí Cabré (ORCID: https://orcid.org/0000-0002-7473-8898)
- Marcos F. Fondevila (ORCID: https://orcid.org/0000-0002-5099-3421)
- Cynthia L. Hsu (ORCID: https://orcid.org/0000-0002-2604-1340)
- H Han
- Cristina Llorente
- Fernanda Raya Tonetti
- Linton Freund
- P Stärkel
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- UCLouvain (BE)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1097/hep.0000000000001744
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00