Advancing towards cancer theragnostic by probing the 225Ac decay chain with ultra-high-resolution metallic magnetic calorimeter based detectors
To the best of our knowledge, this first MMC based X-ray and γ-spectrum of <sup>225</sup>Ac demonstrates the detector's potential, as it enables the separate detection of most nuclides in the <sup>225</sup>Ac decay chain (all except <sup>221</sup>Ra and <sup>217</sup>Rn) with high sensitivity, excellent energy resolution, and precise energy calibration, paving the way for key technological advancements in research and clinical applications in nuclear medicine.
Authors
- A. Fleischmann (ORCID: https://orcid.org/0000-0002-0218-5059)
- Daniel Hengstler
- A. Knecht (ORCID: https://orcid.org/0000-0002-3767-950X)
- L. Gastaldo (ORCID: https://orcid.org/0000-0002-7504-1849)
- Carmen Wängler (ORCID: https://orcid.org/0000-0003-1161-8669)
- Bianca Schacherl (ORCID: https://orcid.org/0000-0003-4542-0108)
- Martin Béhé (ORCID: https://orcid.org/0000-0002-1110-2665)
- Tonya Vitova (ORCID: https://orcid.org/0000-0002-3117-7701)
- C. Enss (ORCID: https://orcid.org/0009-0004-2330-6982)
- Katharina von Schoeler (ORCID: https://orcid.org/0009-0005-2671-5869)
- Kiara Maurer
- D Unger
- Martina Benešová-Schäfer
Institutions
- Karlsruhe Institute of Technology (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Paul Scherrer Institute (CH)
- ETH Zurich (CH)
- Kirchhoff (Germany) (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1038/s43856-026-01377-0
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00